Predictors of low tolerance to physical activity in young and middle-age men

Authors:

Dydyshko Vladislav Tadeevich — PhD in Medical Sciences (Cand. Med. Sci.), lecturer, Hospital Therapy Department, S.M. Kirov Military Medical Academy, 6 Akademika Lebedeva Street, 194044 St. Petersburg, Russian Federation; e-mail: vlad-didishko@mail.ru; https://orcid.org/0000-0002-0244-8672.

Naumkina Polina Ivanovna — 5th year cadet, S.M. Kirov Military Medical Academy, 6 Akademika Lebedeva Street, 194044 St. Petersburg, Russian Federation; e-mail: naumkina.pi@yandex.ru; https://orcid.org/0000-0003-1176-4690.

Grigoriev Stepan Grigoryevich — Grand PhD in Medical Sciences (Dr. Med. Sci.), Professor, senior researcher of the Research Center, S.M. Kirov Military Medical Academy, 6 Akademika Lebedeva Street, 194044 St. Petersburg, Russian Federation; e-mail: gsg_rj@mail.ru; https://orcid.org/0000-0003-1095-1216.

Glebova Svetlana Anatolievna — PhD in Medical Sciences (Cand. Med. Sci.), supervisor of the training center of KardioКlinika, 25 Kuznetsovskaya Street, 196105 St. Petersburg, Russian Federation; e-mail: glebova-sa@ kardioklinika.ru; https://orcid.org/0000-0003-1627- 587X.

Borisova Ekaterina Viktorovna — Grand PhD in Medical Sciences (Dr. Med. Sci.), Chief Physician of KardioKlinika, 25 Kuznetsovskaya Street, 196105 St. Petersburg, Russian Federation; Professor, Department of Internal Diseases, Clinical Pharmacology and Nephrology, North-Western State Medical University named after I.I. Mechnikov, 47 Piskarevsky Ave, 195067 St. Petersburg, Russian Federation; e-mail: borisova-ev@kardioklinika.ru; https://orcid.org/0000-0002-0960-9627.

Barsukov Anton Vladimirovich — Grand PhD in Medical Sciences (Dr. Med. Sci.), Professor, Associate Professor of Hospital Therapy Department, S.M. Kirov Military Medical Academy, 6 Akademika Lebedeva Street, 194044 St. Petersburg, Russian Federation; Deputy Chief Physician of KardioKlinika, 25 Kuznetsovskaya Street, 196105 St. Petersburg, Russian Federation; e-mail: avbarsukov@ yandex.ru; https://orcid.org/0000-0002-1943-9545.

Annotation:

Introduction. Determination of cardiovascular risk is usually carried out in people over 40 years of age, since in most cases under the age of 40 years the absolute risk is low or intermediate, but can be increased by multiple risk factors. Among these risk modifiers, physical inactivity is considered. Determining the degree of physical fitness and functional reserve of the myocardium helps to more accurately determine the state of the cardiovascular system in young and middle-aged men without clinically significant somatic pathology.

Aim. To carry out a comparative assessment of cardiometabolic parameters in 555 young and middle-aged men without clinically significant somatic pathology depending on the status of exercise tolerance and to establish predictors of low exercise tolerance within the totality of the studied indicators.

Materials and methods. We analyzed 555 archival medical records of males aged 30 to 50 years without clinically significant somatic pathology who underwent a screening examination at the therapeutic clinic of the SM Kirov Military Medical Academy. The SCORE2 scale was used to assess the risk of fatal and non-fatal cardiovascular diseases over 10 years in people over 40 years of age. For statistical processing of the study results, the Statistic for Windows software package (version 10) was used.

Results. Men in the age range of 30-50 years with low exercise tolerance compared to those with average and high exercise tolerance are characterized by significantly higher rates reflecting the components of metabolic syndrome and pro-inflammatory status (body mass index, waist circumference, office blood pressure, level of serum triglycerides, fasting glucose, uric acid, fibrinogen).

Discussion. The military-medical significance of the problem under consideration is obvious, since in combination with known risk factors (tobacco smoking, hypertension, poor nutrition, obesity, etc.), low exercise tolerance can affect the quality of life, vital activity, prognosis and requires correction by eliminating the components of the metabolic syndrome, changes in eating habits, physical activity.

Summary. As a result of the study, the structure of cardiometabolic indicators in young and middle-aged men with different exercise tolerance status was clarified, and predictors of low exercise tolerance were established according to ROC analysis. Assessing exercise tolerance in conjunction with determining routine hemodynamic parameters, biochemical blood tests, electrocardiography, and echocardiography will allow optimizing the system of clinical and dynamic monitoring of young and middle-aged individuals in terms of their cardiovascular prognosis.

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