Intravenous laser irradiation of blood in the complex treatment of foot mycoses

Authors:

Alkhilova Sakinat Musalutdinovna, postgraduate student, North-Western State Medical University named after I.I. Mechnikov, 47 Piskarevsky Ave., St. Petersburg, 195067, Russian Federation; tel.: +79993500009; e-mail: alkhilova89@gmail.com; https://orcid.org/0009-0008-8821-0024.

Ponomarenko Inga Gennadievna, Grand PhD in Medical sciences, Associate Professor of Department of Physical and Rehabilitation Medicine, North-Western State Medical University named after I.I. Mechnikov, 47 Piskarevsky Ave., St. Petersburg, 195067, Russian Federation; Associate Professor of the Department of Skin and Venereal Diseases, S.M. Kirov Military Medical Academy, 6 Akademika Lebedeva Str., St. Petersburg, 194044, Russian Federation; tel.: +79218886675; e-mail: manga-85@mail.ru; https://orcid.org /0000-0001-6550-6940.

Kluchareva Svetlana Viktorovna, Grand PhD in Medical sciences, professor, North-Western State Medical University named after I.I. Mechnikov, 47 Piskarevsky Ave., St. Petersburg, 195067, Russian Federation; tel.: +79217473085; e-mail: genasveta@rambler.ru; https://orcid.org /0000-0003-0801-6181.

Annotation:

Introduction. About 70% of the world’s population suffers from foot mycoses, while a steady increase in the number of cases is recorded annually. Modern epidemiological data indicate an increase in the number of patients among people of working age and children due to insufficient diagnostic and preventive measures, low effectiveness of therapy. The treatment of patients with the chronization of the process is long and expensive, often the compliance of patients decreases, as a result, relapses and a progressive course of the disease develop. An urgent task is to develop and put into practice an effective antimycotic treatment complex capable of optimizing and reducing the duration of treatment.

Aim. To develop and scientifically substantiate the use of a complex of antimycotics and low-intensity laser therapy by intravenous laser irradiation of blood in the treatment of patients with foot mycosis in residents of the Republic of North Ossetia.

Materials and methods. The study involved 60 patients (36 women and 24 men over 18 years of age) with a laboratory-confirmed diagnosis of “Mycosis of the feet” (ICD-X: B35.3) Patients of group 1 received traditional therapy: combinations of external and systemic antimycotics, in group 2 an additional course of intravenous laser irradiation of blood was performed out of 10 daily procedures with the laser therapeutic device “Uzormed-B2C”
7 = 405 nm with a power of 3-10 MW for 10-25 minutes. The data on the dynamics of clinical and laboratory studies, quality of life, safety profile of the treatment complex, patient compliance were evaluated, the timing of the onset of the effect of therapy was analyzed. The follow-up period was 12 months.

Results. The relief of the main objective and subjective clinical manifestations occurred significantly earlier in patients in the complex treatment group: by the end of the 1st month, 86-92% of clinical manifestations regressed. The results of a triple microscopic and cultural examination for mycelium of the fungus were negative in 87% of patients after the end of a 6-week course of therapy. Relapses and persistent side effects have not been registered.

Discussion. The therapeutic effects of intravenous laser irradiation of blood make it possible to justify its use in combination with effective etiotropic therapy for the treatment of patients with mycotic infections. Normalization of cellular and humoral links of the immune response, improvement of rheological properties of blood have a pronounced immunocorrective therapeutic effect, contribute to improving clinical results.

Summary. Complex therapy of foot mycoses using low-intensity laser radiation is effective and safe. The approved treatment regimen makes it possible to shorten the time of prescribing hepatotoxic systemic antimycotic drugs, improve patient compliance.

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