Migraine The most common primary headaches (GB) are migraine and tension headache (GBN). Their pathogenesis is multifactorial and is based on the mechanisms of sensitization of central structures and reduction of antinociceptive activity. In both migraine and GBN, there is a change in the processing of nociceptive pain and only minimal nociceptive effects are required … Continue reading Skeletomuscular dysfunctions in primary and secondary headaches: part 1. pathogenesis peculiarities and clinical manifestations: a scientific review